Artikelnummer: 300377

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Human Colon adenocarcinoma cell line
Frozen cryovial
3.5 Mio. cells/ml; 1.5ml
Human Colon adenocarcinoma cell line WiDr

Organism: Homo sapiens (human)
Age: 78 years old
Gender: Female
Tissue: Colon
Morphology: Epithelial
Celltype: Adenocarcinoma, colorectal
Growth Properties: Monolayer, adherent
Description: According to Chen TR, 1987, the WiDr cell line is a derivative of the HT-29 cell line. The cells are negative for Colon Antigen 3 expression, but positive for keratin by immunoperoxidase staining. The cells expressed p53 antigen (the p53 produced has a G -> A mutation resulting in Arg -> His at position 273). Growth of WiDr cells is inhibited by tumor necrosis factor alpha (TNF Inhibitors of dihydrofolate reductase are highly cytotoxic to WiDr cells).